We are a group of researchers dedicated to developing innovative synthetic strategies and tactics for the sustainable and scalable total synthesis of natural products and related chemical space. Our research focuses on fine-tuning molecular architectures to drive natural product–based drug discovery. Along the way, we are also discovering new molecular rearrangements and designing novel reagents to access previously unexplored chemical reactivity.
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Natural Product Synthesis and Drug Discovery:
Natural product synthesis lies at the heart of our research, combining the elegance of organic chemistry with the complexity of biologically active molecules. Nature has evolved an extraordinary array of compounds with potent therapeutic properties, and our goal is to access, understand, and expand upon these molecular architectures through innovative synthetic strategies. By developing efficient and scalable routes to natural products and their analogs, we aim to uncover new chemical space and accelerate drug discovery. Our work bridges fundamental science and real-world impact, contributing to the development of novel treatments for pressing medical challenges. -
Molecular Rearrangements and Novel Reagents Discovery:
Molecular rearrangements and novel reagents development are fundamental strategies in modern synthetic organic chemistry, enabling the efficient and precise construction of complex molecular architectures. Molecular rearrangements, a subclass of organic reactions, involve the reorganization of atomic connectivity within a molecule, often converting simple precursors into structurally intricate and functionally diverse products. These transformations are inherently elegant, highly stereospecific, and exhibit excellent atom economy, making them indispensable tools in organic synthesis. However, they are often challenging to identify during retrosynthetic planning, especially in the context of natural product synthesis. Moreover, most known rearrangements have been explored only within specific chemical systems, leaving vast potential for discovering new reactivity and expanding unexplored chemical space. To address this, we are developing novel molecular rearrangements aimed at enabling the synthesis of complex natural products and facilitating skeletal editing of heterocycles. In parallel, the design of new reagents is central to unlocking unprecedented transformations, offering enhanced selectivity, broader reactivity, and improved sustainability in synthetic methodologies.